Andarine for Sale — Best 99%+ Purity S4 SARM, Third-Party Tested, USA

Andarine for sale — every bottle of our S4 is independently HPLC tested to 99%+ purity, carries a batch-specific Certificate of Analysis, and is manufactured in the USA. If you are searching for andarine for sale with verified, publicly accessible lab documentation you can check before ordering, this is the right source. We offer andarine for sale in liquid solution at 50mg/ml — the highest concentration available on the market — with same-day shipping on all in-stock orders.

Andarine for Sale — The Original SARM, Still One of the Best for Cutting Research

When researchers look for andarine for sale, they are sourcing the compound that started the entire SARM category. Andarine — also known as S4, GTX-007, and S-40503 — was the first selective androgen receptor modulator developed, created by GTX Pharmaceuticals in the early 2000s with the original aim of treating muscle wasting and osteoporosis. Its discovery that a non-steroidal molecule could selectively activate androgen receptors in muscle and bone without the broad systemic effects of testosterone sparked an entire generation of SARM research.

Andarine is an aryl propionamide-derived partial agonist of the androgen receptor. Unlike full agonists such as RAD-140, andarine does not completely activate the receptor — it modulates it. This partial agonism is what gives andarine its distinctive research profile: meaningful anabolic activity in muscle and bone tissue, with reduced activity in non-target organs. Preclinical animal studies have demonstrated significant improvements in bone mineral density, lean mass, and body composition. Andarine is considered less androgenic than RAD-140 or LGD-4033, making it a compound of interest for cutting and body recomposition research rather than pure mass-building protocols.

The single most important factor when sourcing andarine for sale is purity verification. In 2024, independent testing of SARM products from multiple online vendors found significant discrepancies between labelled and actual concentration in over 40% of samples. Our 50mg/ml andarine is verified by an independent ISO/IEC 17025 accredited laboratory — not in-house — with batch-specific COAs publicly posted before every order.

How Andarine Works — Mechanism of Action Explained

Understanding andarine’s mechanism is essential context for any researcher sourcing andarine for sale. S4 operates through selective binding to the androgen receptor (AR) with high affinity, triggering a cascade of cellular responses that promote anabolic activity specifically in muscle and bone tissue.

Selective Androgen Receptor Binding

Andarine binds to the androgen receptor in skeletal muscle and bone with high affinity while displaying significantly reduced activity in androgenic tissues such as the prostate and scalp. This tissue selectivity — the defining characteristic of all SARMs — is achieved through conformational changes in the AR complex that recruit different co-activator proteins in different tissue types. In muscle and bone, the recruited co-activators drive anabolic gene expression. In androgenic tissues, the partial agonism of S4 limits this response.

Partial Agonist Behaviour

Critically, andarine is a partial agonist — not a full agonist — at the androgen receptor. This means it does not completely activate the receptor in any tissue. This partial activation is what distinguishes S4 from stronger SARMs like RAD-140 (a full agonist) and is the reason andarine’s anabolic effects are considered moderate compared to other compounds in the class. Researchers studying dose-response relationships and receptor activation thresholds find andarine particularly valuable for this reason: it allows investigation of partial receptor activation at a controlled, graded level.

Downstream Anabolic Signalling

Upon AR binding, andarine triggers increased protein synthesis and nitrogen retention in muscle tissue. In bone, it promotes osteoblast activity and bone mineral density. Rat studies using 1.6 mg/kg body weight showed significant improvements in bone mineral density, lean mass, and body composition. At 3 mg/kg/day, substantial increases in muscle mass were observed. In the ovariectomized rat model of osteoporosis — the standard preclinical model for postmenopausal bone loss — doses of 3 and 10 mg/kg/day for 8 weeks produced improvements in whole-body bone mineral density.

No Aromatization — No Estrogen Conversion

Unlike testosterone and many anabolic steroids, andarine does not convert to estrogen. Research models using S4 do not exhibit estrogen-mediated side effects such as water retention or gynecomastia. This makes andarine particularly relevant for body composition and cutting research protocols where maintaining a dry, defined muscle phenotype is the research objective.

What Researchers Study With Andarine for Sale

The preclinical literature on andarine covers four primary research domains. Here is what the science supports when researchers source andarine for sale:

Andarine for Sale — Full Research Specifications

How to Find the Best Andarine for Sale — Quality Checklist

The andarine for sale market is crowded and poorly regulated. Product testing by independent researchers has repeatedly found concentration inaccuracies, contaminated solutions, and even mislabelled compounds from low-quality suppliers. Here is exactly what separates trustworthy andarine for sale from what to avoid:

Every bottle of andarine for sale from us covers:

• ✓Identity — Mass Spectrometry
• ✓Purity % — HPLC chromatography
• ✓Concentration accuracy (<5% variance)
• ✓Heavy metals panel
• ✓Microbial limits test
• ✓Batch-specific COA issued

Red Flags When Sourcing Andarine for Sale

• No batch-specific COA — a generic undated lab report is not a COA. It must match the lot number on your bottle.
• Concentration below 50mg/ml — 25mg/ml or 10mg/ml concentrations require larger volumes per research dose and offer worse value. 50mg/ml is the research standard for andarine for sale.
• Plastic bottles — andarine in PEG-400 solution can interact with low-quality plastic over time. UV-resistant glass is the correct container.
• No USP-grade solvent disclosure — PEG-400 used in suspension must be pharmaceutical-grade (USP). Suppliers that do not disclose solvent grade cannot guarantee research integrity.
• Price significantly below market — quality andarine for sale at 50mg/ml runs $50–$80 per 30ml bottle. Significant discounts below this signal purity or concentration shortcuts.

Critical Research Notes — Vision Side Effects & Testosterone Suppression

Responsible sourcing of andarine for sale requires full transparency about the compound’s known preclinical safety profile. Two effects documented in animal studies and community reports must be understood by any researcher working with S4:

Additionally: Andarine has been prohibited by WADA since January 2008 under S1 Anabolic Agents. Blood and urine tests to detect all known SARMs including S4 are available and used in competitive sports. Source: USADA.org ↗

Andarine for Sale vs. Other SARMs — How Does S4 Compare?

Researchers frequently compare compounds when sourcing andarine for sale. Here is how S4 positions relative to the most commonly studied SARMs:

Andarine occupies a specific niche: the strongest cutting-focused SARM with partial agonism. For researchers studying selective receptor modulation at graded activation levels, or investigating cutting and body recomposition applications, andarine for sale remains the most relevant compound in this comparison set. For pure mass-building or muscle wasting research, RAD-140 or LGD-4033 are more appropriate compounds.

Andarine for Sale — Preclinical Dosing Context & Storage

The following is provided strictly for research reference. All andarine for sale on this page is intended for laboratory use only. Not for human consumption.

Published animal studies on andarine use doses ranging from 1.6 mg/kg to 10 mg/kg body weight, administered orally. At 1.6 mg/kg, significant improvements in bone mineral density, lean mass, and body composition were observed. At 3 mg/kg/day, substantial increases in muscle mass were documented. The vision-related side effect (ocular androgen receptor binding) has been observed to increase in frequency and severity at higher doses in preclinical models, providing researchers with a useful dose-dependent biomarker for receptor saturation.

Andarine is orally bioavailable — one of its key practical research advantages. It does not require reconstitution or injection. The 50mg/ml liquid solution is administered using the included graduated glass pipette, allowing precise volume measurement.

Storage & Handling

• Liquid solution: Store in a cool, dry place away from direct sunlight. UV-resistant glass bottle protects against photodegradation.
• Temperature: Room temperature storage is appropriate for andarine solution. Refrigeration is not required but acceptable.
• Shelf life: 24 months from manufacture date when stored correctly. Do not freeze the liquid solution.
• Pipette use: The included graduated 1ml glass pipette allows precise volume measurement. Rinse with solvent between uses to prevent cross-contamination in multi-compound research protocols.

Research Stacking Context for Andarine

For research context only. Not medical advice.

The literature and community research records describe several compound pairings commonly investigated alongside andarine for sale:

• Andarine + RAD-140: Frequently described in community research as a bulking pairing — andarine at 50mg alongside RAD-140 at 10mg. RAD-140’s full agonism provides the primary anabolic stimulus; andarine’s partial agonism provides a secondary, tissue-selective complement. Documented in US Pharmacist’s 2020 recreational SARM use review.
• Andarine + LGD-4033: A strength-focused pairing studied in community literature. LGD-4033’s high-affinity full agonism combined with andarine’s partial agonism for a dual AR modulation research model.
• Andarine + Cardarine (GW-501516): Andarine at 25mg alongside Cardarine at 20mg represents the most documented cutting protocol in community research literature. Cardarine’s PPAR-delta agonism (fat oxidation, endurance) operates through a completely different receptor to andarine’s AR modulation — no mechanistic overlap.
• Andarine standalone: Documented in the literature at 25mg per day for general wellness and mood research, and 50mg per day for lean mass and fat-burning focused protocols.

Browse all SARM research compounds for sale →

Andarine for Sale — Frequently Asked Questions

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  Is andarine for sale legal to buy in the USA?
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  Yes. Andarine for sale in the USA is legal to purchase as a research-use-only (RUO) research chemical. It is legal to sell and buy SARMs marketed as research chemicals, which commonly occurs online (US Pharmacist, 2020). Andarine is not FDA-approved for any medical indication and is not for human consumption. It is prohibited by WADA under S1 Anabolic Agents since January 2008 — competitive athletes in tested sports cannot use it. Sources: USADA ↗  |  US Pharmacist ↗
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  What is andarine S4 and what makes it unique among SARMs?
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  Andarine (S4, GTX-007) is an aryl propionamide-derived partial agonist of the androgen receptor — the first SARM ever developed. Its defining characteristic is partial agonism: unlike full agonist SARMs such as RAD-140 or LGD-4033, andarine does not completely activate the androgen receptor. This produces a moderate anabolic profile with meaningful tissue selectivity, making it particularly useful for cutting, body recomposition, and bone density research. Its discovery sparked the entire SARM research category. It is also the only SARM documented to bind to ocular androgen receptors, producing a unique and reversible vision side effect at higher doses.
• 
  What is the vision side effect of andarine?
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  Andarine is the only SARM documented to bind to androgen receptors in ocular tissue. At higher doses, this binding produces a temporary yellow tint to vision and reduced night vision acuity. The effect is dose-dependent — observed more consistently at higher doses and less frequently at lower doses — and fully reversible upon dose reduction or discontinuation. This side effect was the primary reason human clinical development of andarine was halted in favour of ostarine, which does not exhibit ocular AR binding. Any research protocol involving andarine should monitor for this effect as a dose-dependent biomarker.
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  What purity should andarine for sale have?
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  The minimum acceptable standard for andarine for sale is 99%+ purity verified by independent third-party HPLC testing, with identity confirmed by Mass Spectrometry and a batch-specific COA corresponding to the lot number on your bottle. Additionally, concentration accuracy should be within 5% of the labelled amount — concentration variance above this threshold meaningfully affects research reproducibility. Every bottle of our andarine for sale meets all these standards.
• 
  How does andarine compare to ostarine (MK-2866)?
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  Both andarine and ostarine are partial agonists at the androgen receptor, and both were developed by GTX Pharmaceuticals. However, they differ in key ways. Andarine is considered more potent for muscle and body composition research, produces the unique vision side effect that ostarine does not, and has a narrower research safety window. Ostarine has advanced further in clinical development — reaching Phase 3 trials for cancer cachexia — and has a more established human safety dataset. For cutting-focused research, andarine is generally considered the more active compound. For researchers prioritising a more conservative preclinical safety profile, ostarine is the better choice.
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  Does andarine suppress testosterone?
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  Yes. Like all SARMs, andarine suppresses endogenous testosterone production through HPTA axis modulation. Suppression from S4 is generally considered less severe than from full agonist SARMs like RAD-140 or S23, but it is not negligible. Suppression is dose-dependent and cycle-length dependent. Researchers should design protocols that account for this effect and monitor relevant biomarkers (LH, FSH, total testosterone) throughout the research period.
• 
  What concentration of andarine for sale should I look for?
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  50mg/ml in a 30ml bottle is the standard concentration for andarine for sale and offers the best value per milligram. At this concentration, a standard 30ml bottle contains 1,500mg of andarine. Lower concentrations (25mg/ml or 10mg/ml) require larger volumes per research dose, increasing solvent consumption and reducing cost efficiency. Our andarine for sale is formulated at 50mg/ml in USP-grade PEG-400, the highest concentration available on the market and the research standard.
• 
  Is andarine the same as S4?
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  Yes. Andarine, S4, GTX-007, and S-40503 all refer to the same compound — CAS 401900-40-1. “S4” is the most commonly used shorthand. “Andarine” is the name assigned by GTX Pharmaceuticals. “GTX-007” is the internal development code. All names appear in the published literature and are used interchangeably. When searching for andarine for sale online, all four names return results for the same compound — always verify the CAS number (401900-40-1) on the COA to confirm identity.

Published Research Supporting Andarine for Sale

All references link directly to PubMed or the original publisher for independent verification.

1. Gao W, et al. (2004). Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology. PMID: 15001547 ↗ — Original foundational preclinical data for andarine’s anabolic and bone-protective activity in rodent models.
2. Thevis M, et al. (2010). Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator andarine (S-4) for routine doping control purposes. PMID: 20623476 ↗ — Confirmed andarine’s metabolic profile and detection targets for sports drug testing.
3. Demirtas L, et al. (2023). In vitro anti-carcinogenic effect of andarine as a selective androgen receptor modulator on MIA-PaCa-2 cells by decreased proliferation and cell-cycle arrest at G0/G1 phase. PMID: 37302286 ↗ — First study evaluating andarine’s anti-carcinogenic potential in pancreatic cancer cells. G0/G1 arrest confirmed.
4. Cicek E, et al. (2023). A selective androgen receptor modulator S4 displays robust anti-cancer activity on hepatocellular cancer cells by negatively regulating PI3K/AKT/mTOR signalling pathway. PMID: 36990257 ↗ — S4 significantly impaired HCC growth, migration, proliferation, and induced apoptosis through PI3K/AKT/mTOR inhibition.
5. Toprak M, et al. (2024). Exploring the potentials of S4, a selective androgen receptor modulator, in glioblastoma multiforme therapy. ScienceDirect. Full paper ↗ — Anti-oncogenic activity confirmed in temozolomide-responsive and -resistant glioblastoma cells.
6. Vasireddi N, Hahamyan H, et al. (2025). Emerging Use of SARMs in Orthopaedic Sports Medicine: A Systematic Review. American Journal of Sports Medicine — Andarine cited as one of four most commonly studied SARMs alongside MK-2866, RAD-140, and LGD-4033.
7. USADA (2026). Selective Androgen Receptor Modulators (SARMs) — Prohibited Class: Anabolic Agents. USADA.org ↗ — Andarine (S4) confirmed on WADA prohibited list since January 2008.